Multifocally within the cortex, medulla, and capsule, there are low to moderate numbers of infiltrating plasma cells and lymphocytes. The few remaining cortical cells frequently contain abundant vacuolated cytoplasm (degeneration) with small amounts of yellow-gold, granular pigment (lipofuscin). HISTOPATHOLOGIC DESCRIPTION: Adrenal gland: Diffusely all three cortical zones (zonae glomerulosa, fasciculata, and reticularis) are severely atrophic with loss of cortical architecture (stromal collapse). Slide B: SIGNALMENT (JPC #1669572): 10-year-old, male German shepherd dog MORPHOLOGIC DIAGNOSIS: Adrenal gland, zonae fasciculata and reticularis: Atrophy, diffuse, moderate, German shepherd dog, canine.ĮTIOLOGY: Exogenous corticosteroid administrationĮTIOLOGIC DIAGNOSIS: Iatrogenic adrenocortical atrophy The capsule and connective tissue septa are diffusely moderately expanded by fibrous connective tissue and there are multifocal intracapsular nests of cortical cells. Multifocally, cortical cells near the corticomedullary junction have abundant vacuolated cytoplasm (degeneration) that contains small amounts of yellow-gold, granular pigment (lipofuscin). ![]() HISTOPATHOLOGIC DESCRIPTION: Adrenal gland, adrenal cortex: Diffusely, the zona fasciculata and zona reticularis are severely atrophied, reduced to approximately one-third normal thickness. HISTORY: This dog was intermittently treated with prednisolone for skin allergies. ![]() Slide A: Signalment (JPC #2028971): 12-year-old German shepherd dog
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